InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hoxd11

Summary

InnateDB Protein

IDBP-533280.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxd11

Protein Name

homeobox D11

Synonyms

E230017H14Rik; Hox-4.6; Hox-5.4; Hox-5.5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122582

InnateDB Gene

IDBG-181020 (Hoxd11)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0001656	metanephros development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001759	organ induction
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007338	single fertilization
GO:0007389	pattern specification process
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0010720	positive regulation of cell development
GO:0030326	embryonic limb morphogenesis
GO:0032330	regulation of chondrocyte differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0042733	embryonic digit morphogenesis
GO:0048589	developmental growth
GO:0060272	embryonic skeletal joint morphogenesis
GO:0060351	cartilage development involved in endochondral bone morphogenesis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:96203

InterPro

IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
IPR021918 Domain of unknown function DUF3528, homeobox protein, eukaryotic

PFAM

PF00046
PF12045

PRINTS

PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt