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InnateDB Protein
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IDBP-533352.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Exo5
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Protein Name
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defects in morphology 1 homolog (S. cerevisiae)
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Synonyms
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3110037I16Rik; AV297100; Dem1; Exo V; mExo5;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000116454
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InnateDB Gene
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IDBG-184087 (Exo5)
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Protein Structure
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| Function |
Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Localizes to repair foci in response to DNA damage. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
2 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0045145
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single-stranded DNA 5'-3' exodeoxyribonuclease activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1920422
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| InterPro |
IPR019190
Exonuclease V
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| PFAM |
PF09810
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
Z4YLZ9
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| UniProt Splice Variant |
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| Entrez Gene |
73172
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| UniGene |
Mm.484289
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Exo5
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL606904
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| GenPept |
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Version 5.4