InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ubc

Summary

InnateDB Protein

IDBP-533427.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubc

Protein Name

ubiquitin C

Synonyms

2700054O04Rik; AI194771; Rps27a; TI-225; Uba52; Ubb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115578

InnateDB Gene

IDBG-201307 (Ubc)

Protein Structure

UniProt Annotation

Function

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269PubMed:19754430}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 362 experimentally validated interaction(s) in this database.
They are also associated with 8383 interaction(s) predicted by orthology.

Experimentally validated
Total	362 [view]
Protein-Protein	362 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8383 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007141	male meiosis I
GO:0007144	female meiosis I
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0010992	ubiquitin homeostasis
GO:0021888	hypothalamus gonadotrophin-releasing hormone neuron development
GO:0060612	adipose tissue development
GO:0060613	fat pad development
GO:0072520	seminiferous tubule development
GO:0097009	energy homeostasis