Version 5.4
Mus musculus Protein: Cd84
Summary
InnateDB Protein IDBP-533441.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd84
Protein Name CD84 antigen
Synonyms A130013D22Rik; CDw84; SLAMF5;
Species Mus musculus
Ensembl Protein ENSMUSP00000120881
InnateDB Gene IDBG-204869 (Cd84)
Protein Structure
UniProt Annotation
Function Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. {ECO:0000269PubMed:16037392}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in hematopoietic tissues such as lymph node, spleen, thymus, and bone marrow. Detected also in lung.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1336885
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q18PI6
PhosphoSite PhosphoSite-Q18PI6
TrEMBL
UniProt Splice Variant
Entrez Gene 12523
UniGene Mm.390433
RefSeq NP_038517
MGI ID
MGI Symbol Cd84
OMIM
CCDS CCDS15503
HPRD
IMGT
EMBL AB196812 AB196813 AB196814 AB196815 AF043445 AK037385 AK040694 AK154834 AK156464 AK157075 AK171067
GenPept AAD02273 BAC29799 BAC30670 BAE32863 BAE33721 BAE33953 BAE42226 BAE96315 BAE96316 BAE96317 BAE96318

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca