InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tln1

Summary

InnateDB Protein

IDBP-533516.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tln1

Protein Name

talin 1

Synonyms

Tln;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119441

InnateDB Gene

IDBG-141551 (Tln1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0017166	vinculin binding
GO:0030274	LIM domain binding

Biological Process

GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007044	cell-substrate junction assembly
GO:0030866	cortical actin cytoskeleton organization

Cellular Component

GO:0005813	centrosome
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1099832

InterPro

IPR000299 FERM domain
IPR018979 FERM, N-terminal
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR029071 Ubiquitin-related domain

PFAM

PF09379
PF00373

PRINTS

PIRSF

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A2AIM2

UniProt Splice Variant

Entrez Gene

21894

UniGene

Mm.482187

RefSeq

MGI ID

MGI Symbol

Tln1

OMIM

CCDS

HPRD

IMGT

EMBL

AL732506

GenPept