Version 5.4
Mus musculus Protein: Nrg4
Summary
InnateDB Protein IDBP-533599.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nrg4
Protein Name neuregulin 4
Synonyms AI552600;
Species Mus musculus
Ensembl Protein ENSMUSP00000115247
InnateDB Gene IDBG-167795 (Nrg4)
Protein Structure
UniProt Annotation
Function Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. {ECO:0000269PubMed:10348342}.
Subcellular Localization Pro-neuregulin-4, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.Neuregulin-4: Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in pancreas; weakly expressed in muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1933833
InterPro IPR000742 Epidermal growth factor-like domain
PFAM PF00008
PRINTS
PIRSF
SMART SM00181
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WTX4
PhosphoSite PhosphoSite-
TrEMBL D3Z0G2
UniProt Splice Variant
Entrez Gene 83961
UniGene Mm.466946
RefSeq XP_006511631
MGI ID
MGI Symbol Nrg4
OMIM
CCDS CCDS52801
HPRD
IMGT
EMBL AC157328 AF083067 CT025532
GenPept AAD21874

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca