InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Park7

Summary

InnateDB Protein

IDBP-533655.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Park7

Protein Name

Parkinson disease (autosomal recessive, early onset) 7

Synonyms

DJ-1; Dj1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115875

InnateDB Gene

IDBG-205876 (Park7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0008233	peptidase activity
GO:0042803	protein homodimerization activity
GO:0051920	peroxiredoxin activity

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0006508	proteolysis
GO:0008283	cell proliferation
GO:0008344	adult locomotory behavior
GO:0032091	negative regulation of protein binding
GO:0034614	cellular response to reactive oxygen species
GO:0042542	response to hydrogen peroxide
GO:0042743	hydrogen peroxide metabolic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0050821	protein stabilization
GO:0051583	dopamine uptake involved in synaptic transmission
GO:0051899	membrane depolarization
GO:0055114	oxidation-reduction process
GO:0060081	membrane hyperpolarization
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070301	cellular response to hydrogen peroxide
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:2135637

InterPro

IPR002818 ThiJ/PfpI
IPR006287 DJ-1
IPR029062 Class I glutamine amidotransferase-like

PFAM

PF01965

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A2A817

UniProt Splice Variant

Entrez Gene

57320

UniGene

RefSeq

MGI ID

MGI Symbol

Park7

OMIM

CCDS

HPRD

IMGT

EMBL

AL607084

GenPept