InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sv2c

Summary

InnateDB Protein

IDBP-533696.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sv2c

Protein Name

synaptic vesicle glycoprotein 2c

Synonyms

4930527L09Rik; AI841971;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124473

InnateDB Gene

IDBG-174221 (Sv2c)

Protein Structure

UniProt Annotation

Function

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}.Receptor for the botulinium neurotoxin type A/BOTA. {ECO:0000269PubMed:16543415, ECO:0000269PubMed:16545378}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in specific subsets of conventional synapses in the retina (at protein level). {ECO:0000269PubMed:12687700}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006836	neurotransmitter transport
GO:0007268	synaptic transmission
GO:0055085	transmembrane transport

Cellular Component

GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane

Protein Structure and Domains

PDB ID

MGI:1922459

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
IPR022308 Synaptic vesicle protein SV2

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q69ZS6

PhosphoSite