Version 5.4
Mus musculus Protein: Prkrip1
Summary
InnateDB Protein IDBP-533699.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prkrip1
Protein Name Prkr interacting protein 1 (IL11 inducible)
Synonyms 8430424D23Rik; C114;
Species Mus musculus
Ensembl Protein ENSMUSP00000120659
InnateDB Gene IDBG-204476 (Prkrip1)
Protein Structure
UniProt Annotation
Function Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity. {ECO:0000269PubMed:12679338}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12679338}.
Disease Associations
Tissue Specificity Broadly expressed, with highest levels in liver, kidney, brain and heart. {ECO:0000269PubMed:12679338}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0003014 renal system process
GO:0006469 negative regulation of protein kinase activity
GO:0042326 negative regulation of phosphorylation
Cellular Component
GO:0005730 nucleolus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1914051
InterPro IPR009548 Protein of unknown function DUF1168
PFAM PF06658
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CWV6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66801
UniGene Mm.426432
RefSeq NP_080050
MGI ID
MGI Symbol Prkrip1
OMIM
CCDS CCDS19754
HPRD
IMGT
EMBL AK010359 AK010961 AK018438 AK046035 AK088862 BC027503
GenPept AAH27503 BAB26879 BAB27293 BAB31212 BAC32579 BAC40620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca