InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spdya

Summary

InnateDB Protein

IDBP-533707.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spdya

Protein Name

speedy homolog A (Xenopus laevis)

Synonyms

4921517J08Rik; 4930548B21Rik; GS4; MLZ-465; Spdy1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118994

InnateDB Gene

IDBG-197047 (Spdya)

Protein Structure

UniProt Annotation

Function

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2. {ECO:0000269PubMed:15611625}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20339383}.

Disease Associations

Tissue Specificity

Expressed at a high level in testis. Also expressed in the adult ovary and in immature oocytes. {ECO:0000269PubMed:11730327, ECO:0000269PubMed:15611625, ECO:0000269PubMed:20339383}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019901	protein kinase binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006974	cellular response to DNA damage stimulus
GO:0007140	male meiosis
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity