Version 5.4
Mus musculus Protein: Pag1
Summary
InnateDB Protein IDBP-533717.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pag1
Protein Name phosphoprotein associated with glycosphingolipid microdomains 1
Synonyms Cbp; F730007C19Rik; Pag;
Species Mus musculus
Ensembl Protein ENSMUSP00000124529
InnateDB Gene IDBG-131044 (Pag1)
Protein Structure
UniProt Annotation
Function Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269PubMed:12218089, ECO:0000269PubMed:12612075, ECO:0000269PubMed:14645715, ECO:0000269PubMed:16166631}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11777944, ECO:0000269PubMed:12612075, ECO:0000269PubMed:14645715, ECO:0000269PubMed:16166631}; Single-pass type III membrane protein {ECO:0000269PubMed:11777944, ECO:0000269PubMed:12612075, ECO:0000269PubMed:14645715, ECO:0000269PubMed:16166631}. Note=Present in lipid rafts.
Disease Associations
Tissue Specificity Present in T-cells (at protein level). {ECO:0000269PubMed:16166631}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042169 SH2 domain binding
Biological Process
GO:0002376 immune system process
GO:0035556 intracellular signal transduction
GO:0050863 regulation of T cell activation
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID MGI:2443160
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U1F9
PhosphoSite PhosphoSite-Q3U1F9
TrEMBL A6H659
UniProt Splice Variant
Entrez Gene 94212
UniGene Mm.486503
RefSeq NP_001181960
MGI ID
MGI Symbol Pag1
OMIM
CCDS CCDS17235
HPRD
IMGT
EMBL AF250192 AK040230 AK089329 AK156000 AK172106 BC145328 BC145761 BC145763 CH466577
GenPept AAG44565 AAI45329 AAI45762 AAI45764 BAC30545 BAC40842 BAE33539 BAE42829 EDL05179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca