InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab17

Summary

InnateDB Protein

IDBP-533727.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab17

Protein Name

RAB17, member RAS oncogene family

Synonyms

AW413472;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122178

InnateDB Gene

IDBG-180379 (Rab17)

Protein Structure

UniProt Annotation

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post- endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration. {ECO:0000269PubMed:21291502, ECO:0000269PubMed:22291024, ECO:0000269PubMed:9490718, ECO:0000269PubMed:9624171}.

Subcellular Localization

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cell projection, dendrite. Note=According to a report the protein is localized at the basolateral and apical plasma membrane of kidney epithelial cells (PubMed:8486736). It was later shown to localize to the apical recycling endosome in epithelial cells (PubMed:21291502). In neurons, localizes to the cell body and dendritic shaft and spine. {ECO:0000269PubMed:21291502, ECO:0000269PubMed:8486736}.

Disease Associations

Tissue Specificity

Expressed in kidney, liver, and intestine mainly by epithelial cells. Expressed in hippocampus (at protein level). {ECO:0000269PubMed:22291024, ECO:0000269PubMed:8486736}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0002415	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0032401	establishment of melanosome localization
GO:0032402	melanosome transport
GO:0032456	endocytic recycling
GO:0045056	transcytosis
GO:0046847	filopodium assembly
GO:0050773	regulation of dendrite development
GO:0051489	regulation of filopodium assembly
GO:0051963	regulation of synapse assembly

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030425	dendrite
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane

Protein Structure and Domains

PDB ID

MGI:104640

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670
PF08477

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt