InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rpl13a

Summary

InnateDB Protein

IDBP-533747.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rpl13a

Protein Name

ribosomal protein L13A

Synonyms

1810026N22Rik; Tstap198-7; tum-antigen;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115722

InnateDB Gene

IDBG-181665 (Rpl13a)

Protein Structure

UniProt Annotation

Function

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma- induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. {ECO:0000250, ECO:0000269PubMed:23071094}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome

Biological Process

GO:0006412	translation
GO:0017148	negative regulation of translation
GO:0032496	response to lipopolysaccharide
GO:0032844	regulation of homeostatic process
GO:0048246	macrophage chemotaxis
GO:0060425	lung morphogenesis
GO:0071346	cellular response to interferon-gamma