InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Furin

Summary

InnateDB Protein

IDBP-533755.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Furin

Protein Name

furin (paired basic amino acid cleaving enzyme)

Synonyms

9130404I01Rik; Fur; PACE; Pcsk3; SPC1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121028

InnateDB Gene

IDBG-195335 (Furin)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004252	serine-type endopeptidase activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0042277	peptide binding
GO:0048406	nerve growth factor binding

Biological Process

GO:0006465	signal peptide processing
GO:0006508	proteolysis
GO:0008283	cell proliferation
GO:0009966	regulation of signal transduction
GO:0010951	negative regulation of endopeptidase activity
GO:0016485	protein processing
GO:0016486	peptide hormone processing
GO:0019058	viral life cycle
GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0032902	nerve growth factor production
GO:0032911	negative regulation of transforming growth factor beta1 production
GO:0032940	secretion by cell
GO:0043043	peptide biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0009986	cell surface
GO:0012510	trans-Golgi network transport vesicle membrane
GO:0016021	integral component of membrane
GO:0030140	trans-Golgi network transport vesicle
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:97513

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YTP7

UniProt Splice Variant

Entrez Gene

18550

UniGene

Mm.5241

RefSeq

MGI ID

MGI Symbol

Furin

OMIM

CCDS

HPRD

IMGT

EMBL

AC136740

GenPept