InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rffl

Summary

InnateDB Protein

IDBP-533787.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rffl

Protein Name

ring finger and FYVE like domain containing protein

Synonyms

1700051E09Rik; 4930516L10Rik; BG080975; Carp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115846

InnateDB Gene

IDBG-204769 (Rffl)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0002039	p53 binding
GO:0004842	ubiquitin-protein transferase activity
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006886	intracellular protein transport
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936	protein K48-linked ubiquitination
GO:1901797	negative regulation of signal transduction by p53 class mediator
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Cellular Component

GO:0002947	tumor necrosis factor receptor superfamily complex
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016023	cytoplasmic membrane-bounded vesicle

Protein Structure and Domains

PDB ID

MGI:1914588

InterPro

IPR011011 Zinc finger, FYVE/PHD-type

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q6YAT6

UniProt Splice Variant

Entrez Gene

67338

UniGene

Mm.341608

RefSeq

MGI ID

MGI Symbol

Rffl

OMIM

CCDS

HPRD

IMGT

EMBL

AL645594 AL646089 AY163902

GenPept

AAO42677