Version 5.4
Homo sapiens Protein: CDX1
Summary
InnateDB Protein IDBP-53385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDX1
Protein Name caudal type homeobox 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000231656
InnateDB Gene IDBG-53381 (CDX1)
Protein Structure
UniProt Annotation
Function Could play a role in the terminal differentiation of the intestine.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Intestinal epithelium.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007389 pattern specification process
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060349 bone morphogenesis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000047 Helix-turn-helix motif
IPR001356 Homeobox domain
IPR006820 Caudal-like activation domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PF04731
PRINTS PR00031
PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47902
PhosphoSite PhosphoSite-P47902
TrEMBL
UniProt Splice Variant
Entrez Gene 1044
UniGene Hs.1545
RefSeq NP_001795
HUGO HGNC:1805
OMIM 600746
CCDS CCDS4304
HPRD 02849
IMGT
EMBL AF239666 BC096251 U15212 U16360 U51095
GenPept AAA80284 AAB40602 AAC50237 AAF61234 AAH96251

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca