InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Meaf6

Summary

InnateDB Protein

IDBP-533916.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Meaf6

Protein Name

MYST/Esa1-associated factor 6

Synonyms

2310005N01Rik; 2810036M01Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122288

InnateDB Gene

IDBG-187451 (Meaf6)

Protein Structure

UniProt Annotation

Function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043968	histone H2A acetylation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043983	histone H4-K12 acetylation
GO:0044154	histone H3-K14 acetylation

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0035267	NuA4 histone acetyltransferase complex
GO:0070776	MOZ/MORF histone acetyltransferase complex