InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fcho1

Summary

InnateDB Protein

IDBP-533917.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fcho1

Protein Name

FCH domain only 1

Synonyms

3322402E17Rik; N28152;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117606

InnateDB Gene

IDBG-166990 (Fcho1)

Protein Structure

UniProt Annotation

Function

Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly detected in brain and spleen. {ECO:0000269PubMed:21762413}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035612	AP-2 adaptor complex binding

Biological Process

GO:0006886	intracellular protein transport
GO:0016192	vesicle-mediated transport
GO:0048268	clathrin coat assembly
GO:0072583	clathrin-mediated endocytosis

Cellular Component

GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0030131	clathrin adaptor complex
GO:0030136	clathrin-coated vesicle

Protein Structure and Domains

PDB ID

MGI:1921265

InterPro

IPR001060 FCH domain
IPR008968 Clathrin adaptor, mu subunit, C-terminal
IPR018808 Muniscin C-terminal

PFAM

PF00611
PF00928
PF10291

PRINTS

PIRSF

SMART

SM00055

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K285

PhosphoSite

PhosphoSite-Q8K285

TrEMBL

D3Z6N2

UniProt Splice Variant

Entrez Gene

74015

UniGene

Mm.416596

RefSeq

XP_006509832

MGI ID

MGI Symbol

Fcho1

OMIM

CCDS

HPRD

IMGT

EMBL

AC162033 BC032207

GenPept

AAH32207