InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Als2cl

Summary

InnateDB Protein

IDBP-534013.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Als2cl

Protein Name

ALS2 C-terminal like

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115718

InnateDB Gene

IDBG-202499 (Als2cl)

Protein Structure

UniProt Annotation

Function

Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15388334, ECO:0000269PubMed:17239822}. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, lung, liver and kidney. {ECO:0000269PubMed:15388334}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017137	Rab GTPase binding
GO:0042802	identical protein binding

Biological Process

GO:0007032	endosome organization
GO:0008104	protein localization
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043547	positive regulation of GTPase activity