InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clstn2

Summary

InnateDB Protein

IDBP-534043.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clstn2

Protein Name

calsyntenin 2

Synonyms

2900042C18Rik; AI448973; Cs2; Cst-2; CSTN2; mKIAA4134;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124081

InnateDB Gene

IDBG-192321 (Clstn2)

Protein Structure

UniProt Annotation

Function

May modulate calcium-mediated postsynaptic signals. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269PubMed:12498782}. Golgi apparatus membrane {ECO:0000269PubMed:12498782}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization.

Disease Associations

Tissue Specificity

Restricted to the brain. In the cerebral cortex, found in the somas and neuropil of all layers. Expressed at highest levels in neurons of cortical layers 5 and 6 and, at lower levels, in neurons of the upper layers. Highly expressed in Purkinje cells. Also found in a few scattered interneurons throughout the granule cell layer and occasionally in neurons in the molecular layer (at protein level). Present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern). {ECO:0000269PubMed:12498782}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0007156

homophilic cell adhesion

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1929897

InterPro

IPR002126 Cadherin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR015919 Cadherin-like

PFAM

PF00028

PRINTS

PR00205

PIRSF

SMART

SM00112

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ER65

PhosphoSite

PhosphoSite-Q9ER65

TrEMBL

UniProt Splice Variant

Entrez Gene

64085

UniGene

Mm.440903

RefSeq

XP_006511397

MGI ID

MGI Symbol

Clstn2

OMIM

CCDS

HPRD

IMGT

EMBL

AJ278069 AK048369 AK220500 BC063058

GenPept

AAH63058 BAC33313 BAD90297 CAC14887