Version 5.4
Mus musculus Protein: Cdk1
Summary
InnateDB Protein IDBP-534112.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdk1
Protein Name cyclin-dependent kinase 1
Synonyms Cdc2; Cdc2a; p34;
Species Mus musculus
Ensembl Protein ENSMUSP00000119085
InnateDB Gene IDBG-160472 (Cdk1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 146 interaction(s) predicted by orthology.
Experimentally validated
Total 125 [view]
Protein-Protein 125 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 146 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030332 cyclin binding
GO:0030544 Hsp70 protein binding
GO:0035173 histone kinase activity
Biological Process
GO:0006461 protein complex assembly
GO:0006468 protein phosphorylation
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007569 cell aging
GO:0009636 response to toxic substance
GO:0010628 positive regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0014075 response to amine
GO:0014823 response to activity
GO:0016572 histone phosphorylation
GO:0030261 chromosome condensation
GO:0031100 organ regeneration
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0034501 protein localization to kinetochore
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0045471 response to ethanol
GO:0045740 positive regulation of DNA replication
GO:0045931 positive regulation of mitotic cell cycle
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0048678 response to axon injury
GO:0055015 ventricular cardiac muscle cell development
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0070301 cellular response to hydrogen peroxide
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
GO:0030496 midbody
Protein Structure and Domains
PDB ID MGI:88351
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z2T9
UniProt Splice Variant
Entrez Gene 12534
UniGene Mm.281367
RefSeq
MGI ID
MGI Symbol Cdk1
OMIM
CCDS
HPRD
IMGT
EMBL AC131795
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca