InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arl4c

Summary

InnateDB Protein

IDBP-534125.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arl4c

Protein Name

ADP-ribosylation factor-like 4C

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124344

InnateDB Gene

IDBG-179605 (Arl4c)

Protein Structure

UniProt Annotation

Function

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP- bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, filopodium {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0043014	alpha-tubulin binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0032456	endocytic recycling

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030175	filopodium

Protein Structure and Domains

PDB ID

MGI:2445172

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477
PF09439

PRINTS

PR00315
PR00449
PR00328

PIRSF

SMART

SM00175
SM00178
SM00177

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt