Version 5.4
Mus musculus Protein: March11
Summary
InnateDB Protein IDBP-534383.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol March11
Protein Name membrane-associated ring finger (C3HC4) 11
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000118729
InnateDB Gene IDBG-131304 (March11)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID MGI:3608327
InterPro IPR011016 Zinc finger, RING-CH-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF12906
PF00097
PRINTS
PIRSF
SMART SM00744
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CBH7
PhosphoSite PhosphoSite-Q8CBH7
TrEMBL
UniProt Splice Variant
Entrez Gene 211147
UniGene Mm.54257
RefSeq NP_808265
MGI ID
MGI Symbol March11
OMIM
CCDS CCDS27401
HPRD
IMGT
EMBL AC102845 AK035990 BC139422 BC139423
GenPept AAI39423 AAI39424 BAC29270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca