InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyb5

Summary

InnateDB Protein

IDBP-534392.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyb5

Protein Name

cytochrome b-5

Synonyms

0610009N12Rik; Cyb5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124480

InnateDB Gene

IDBG-162759 (Cyb5)

Protein Structure

UniProt Annotation

Function

Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-5 double bond introduction during the C-5 desaturation.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004768	stearoyl-CoA 9-desaturase activity
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006631	fatty acid metabolic process
GO:0046686	response to cadmium ion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome