Version 5.4
Mus musculus Protein: Heg1
Summary
InnateDB Protein IDBP-534657.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Heg1
Protein Name HEG homolog 1 (zebrafish)
Synonyms 4632417D23Rik; 5530401I02Rik; 9530025L16Rik; BC038614; Gm629; OTTMUSG00000027315;
Species Mus musculus
Ensembl Protein ENSMUSP00000119790
InnateDB Gene IDBG-155626 (Heg1)
Protein Structure
UniProt Annotation
Function Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May be acting by stabilizing endothelial cell junctions. {ECO:0000269PubMed:19151727}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000269PubMed:19151727}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0001885 endothelial cell development
GO:0001886 endothelial cell morphogenesis
GO:0001944 vasculature development
GO:0001945 lymph vessel development
GO:0003017 lymph circulation
GO:0003209 cardiac atrium morphogenesis
GO:0003281 ventricular septum development
GO:0007043 cell-cell junction assembly
GO:0007507 heart development
GO:0009791 post-embryonic development
GO:0030324 lung development
GO:0035264 multicellular organism growth
GO:0045216 cell-cell junction organization
GO:0048845 venous blood vessel morphogenesis
GO:0050878 regulation of body fluid levels
GO:0060039 pericardium development
Cellular Component
GO:0005911 cell-cell junction
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1924696
InterPro IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
PFAM PF00008
PF07645
PRINTS
PIRSF
SMART SM00181
SM00179
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E9Q7X6
PhosphoSite PhosphoSite-E9Q7X6
TrEMBL Q6DFX1
UniProt Splice Variant
Entrez Gene 77446
UniGene Mm.409006
RefSeq
MGI ID
MGI Symbol Heg1
OMIM
CCDS
HPRD
IMGT
EMBL AC121570 AK028518 AK163128 BC072651 BC076596 CH466521
GenPept AAH72651 AAH76596 BAC25987 BAE37205 EDK97850

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca