Version 5.4
Homo sapiens Protein: DRAM1
Summary
InnateDB Protein IDBP-53474.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DRAM1
Protein Name DNA-damage regulated autophagy modulator 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000258534
InnateDB Gene IDBG-53472 (DRAM1)
Protein Structure
UniProt Annotation
Function Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy. {ECO:0000269PubMed:16839881, ECO:0000269PubMed:17304243}.
Subcellular Localization Lysosome membrane {ECO:0000269PubMed:16839881}; Multi-pass membrane protein {ECO:0000269PubMed:16839881}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006914 autophagy
GO:0030262 apoptotic nuclear changes
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR019402 Frag1/DRAM/Sfk1
PFAM PF10277
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N682
PhosphoSite PhosphoSite-Q8N682
TrEMBL A0A024RBF9
UniProt Splice Variant
Entrez Gene 55332
UniGene Hs.525634
RefSeq NP_060840
HUGO HGNC:25645
OMIM 610776
CCDS CCDS41823
HPRD 07743
IMGT
EMBL AK002121 BC013773 BC018435 CH471054
GenPept AAH13773 AAH18435 BAA92091 EAW97685 EAW97686

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca