InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: D2Ertd750e

Summary

InnateDB Protein

IDBP-534784.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

D2Ertd750e

Protein Name

DNA segment, Chr 2, ERATO Doi 750, expressed

Synonyms

1700025D04Rik; C15orf23; D2Ertd750e; SKAP; Traf4af1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115860

InnateDB Gene

IDBG-198638 (D2Ertd750e)

Protein Structure

UniProt Annotation

Function

Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore- microtubule interface (By similarity). The astrin (SPAG5)- kinastrin (SKAP) complex localizes to the microtubule plus ends (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0007051	spindle organization
GO:0007059	chromosome segregation
GO:0051988	regulation of attachment of spindle microtubules to kinetochore

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0035371	microtubule plus-end
GO:0072686	mitotic spindle