InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mef2a

Summary

InnateDB Protein

IDBP-534870.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mef2a

Protein Name

myocyte enhancer factor 2A

Synonyms

A430079H05Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117496

InnateDB Gene

IDBG-192076 (Mef2a)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Widely expressed though mainly restricted to skeletal and cardiac muscle, brain, neurons and lymphocytes. Differentially expressed depending on if isoforms contain the beta domain or not, with the total expression of the beta domain- lacking isoforms vastly exceding that of the beta domain- containing isoforms. Isoforms containing the beta domain are expressed primarily in skeletal and cardiac muscle and in brain. Also present in lung and testis. Splicing to include the beta domain is induced in differentiating myocytes. Isoforms lacking the beta domain are expressed less abundantly in skeletal muscle, brain and lymphocytes, and are uniquely found in ovary, liver, spleen and kidney. In embryos, the beta domain-containing and beta domain-lacking isoforms are equally expressed. Also expressed cerebellar granule neurons and other regions of the CNS. Highest levels in the olfactory bulb, cortex, hippocampus, thalamus and cerebellum. {ECO:0000269PubMed:15834131, ECO:0000269PubMed:9013788}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0033613	activating transcription factor binding
GO:0035035	histone acetyltransferase binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046332	SMAD binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000002	mitochondrial genome maintenance
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007399	nervous system development
GO:0007507	heart development
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048311	mitochondrion distribution
GO:0055005	ventricular cardiac myofibril assembly
GO:0061337	cardiac conduction
GO:0070375	ERK5 cascade
GO:0071277	cellular response to calcium ion