Version 5.4
Mus musculus Protein: Cnksr3
Summary
InnateDB Protein IDBP-534875.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnksr3
Protein Name Cnksr family member 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000115863
InnateDB Gene IDBG-129959 (Cnksr3)
Protein Structure
UniProt Annotation
Function Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway. {ECO:0000269PubMed:19567370}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in kidney. {ECO:0000269PubMed:19567370}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0009966 regulation of signal transduction
GO:0010765 positive regulation of sodium ion transport
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:2000651 positive regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2674130
InterPro IPR001478 PDZ domain
IPR010599 Connector enhancer of kinase suppressor of ras 2
PFAM PF00595
PF13180
PF06663
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMA3
PhosphoSite PhosphoSite-Q8BMA3
TrEMBL
UniProt Splice Variant
Entrez Gene 215748
UniGene Mm.37984
RefSeq
MGI ID
MGI Symbol Cnksr3
OMIM
CCDS
HPRD
IMGT
EMBL AK033015 AK149951 AY151137 BC031194
GenPept AAH31194 AAN72835 BAC28127 BAE29189

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca