Version 5.4
Mus musculus Protein: Hal
Summary
InnateDB Protein IDBP-534917.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hal
Protein Name histidine ammonia lyase
Synonyms his; histidase; Hsd;
Species Mus musculus
Ensembl Protein ENSMUSP00000123336
InnateDB Gene IDBG-185946 (Hal)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations Note=Defects in Hal are the cause of histidinemia (His).
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004397 histidine ammonia-lyase activity
GO:0016841 ammonia-lyase activity
Biological Process
GO:0006548 histidine catabolic process
GO:0009058 biosynthetic process
GO:0019556 histidine catabolic process to glutamate and formamide
GO:0019557 histidine catabolic process to glutamate and formate
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:96010
InterPro IPR001106 Aromatic amino acid lyase
IPR005921 Histidine ammonia-lyase
IPR008948 L-Aspartase-like
PFAM PF00221
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35492
PhosphoSite PhosphoSite-P35492
TrEMBL B2RXW1
UniProt Splice Variant
Entrez Gene 15109
UniGene Mm.400768
RefSeq NP_034531
MGI ID
MGI Symbol Hal
OMIM
CCDS CCDS36036
HPRD
IMGT
EMBL AK014518 BC057637 BC157999 CH466539 L07645
GenPept AAA37777 AAH57637 AAI58000 BAB29407 EDL21557

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca