Version 5.4
Mus musculus Protein: Trove2
Summary
InnateDB Protein IDBP-535038.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trove2
Protein Name TROVE domain family, member 2
Synonyms 1810007I17Rik; A530054J02Rik; AI646302; SS-A/Ro; Ssa; Ssa2;
Species Mus musculus
Ensembl Protein ENSMUSP00000125623
InnateDB Gene IDBG-197059 (Trove2)
Protein Structure
UniProt Annotation
Function RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. {ECO:0000269PubMed:21289087}.May play roles in cilia formation and/or maintenance. {ECO:0000269PubMed:21289087}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.
Disease Associations
Tissue Specificity Highest in brain, followed by lung, muscle, kidney and heart. Lower levels are found in testis, liver and spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0030620 U2 snRNA binding
GO:0034336 misfolded RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0002520 immune system development
GO:0007224 smoothened signaling pathway
GO:0009411 response to UV
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID MGI:106652
InterPro IPR002035 von Willebrand factor, type A
IPR008858 TROVE
PFAM PF00092
PF05731
PRINTS
PIRSF
SMART SM00327
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08848
PhosphoSite PhosphoSite-O08848
TrEMBL Q3TJ75
UniProt Splice Variant
Entrez Gene 20822
UniGene Mm.408457
RefSeq NP_038863
MGI ID
MGI Symbol Trove2
OMIM
CCDS CCDS15345
HPRD
IMGT
EMBL AF042139 AF065398 AK167379 AK167555 AK167645 CH466520 U66843
GenPept AAC15667 AAC53142 AAF19049 BAE39472 BAE39620 BAE39696 EDL39511

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca