Version 5.4
Mus musculus Protein: Fktn
Summary
InnateDB Protein IDBP-535072.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fktn
Protein Name fukutin
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000114699
InnateDB Gene IDBG-148137 (Fktn)
Protein Structure
UniProt Annotation
Function May be a glycosyltransferase which participates in glycosylation of alpha-dystroglycan/DAG1. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development. {ECO:0000269PubMed:19017726}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity According to PubMed:12471058: predominantly detected in brain, liver and kidney. According to PubMed:12408965: detected in all adult tissues examined.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016740 transferase activity
Biological Process
GO:0001764 neuron migration
GO:0008152 metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0046329 negative regulation of JNK cascade
GO:0060049 regulation of protein glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2179507
InterPro IPR007074 LicD
IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain
PFAM PF04991
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R507
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 246179
UniGene Mm.490731
RefSeq XP_006538004
MGI ID
MGI Symbol Fktn
OMIM
CCDS CCDS18191
HPRD
IMGT
EMBL AB077383 AJ511807 AK085931 BC017538
GenPept AAH17538 BAB87769 BAC39572 CAD54302

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca