Mus musculus Protein: Lrrtm4
Summary
InnateDB Protein IDBP-535218.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrrtm4
Protein Name leucine rich repeat transmembrane neuronal 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000117445
InnateDB Gene IDBG-158745 (Lrrtm4)
Protein Structure
UniProt Annotation
Function May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly in the brain (at protein level). Also expressed in the cerebellum and other tissues. {ECO:0000269PubMed:12676565, ECO:0000269PubMed:22632720}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043395 heparan sulfate proteoglycan binding
Biological Process
GO:0072578 neurotransmitter-gated ion channel clustering
GO:0097113 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:1901629 regulation of presynaptic membrane organization
Cellular Component
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:2389180
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80XG9
PhosphoSite PhosphoSite-Q80XG9
TrEMBL Q8BYQ8
UniProt Splice Variant
Entrez Gene 243499
UniGene Mm.94135
RefSeq
MGI ID
MGI Symbol Lrrtm4
OMIM
CCDS CCDS20259
HPRD
IMGT
EMBL AC113206 AC153827 AC153839 AC153993 AC153996 AC156282 AC157023 AK032470 AK038656 AY182031 BC037216
GenPept AAH37216 AAO67552 BAC27887 BAC30084