InnateDB Protein
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IDBP-535252.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pitpnc1
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Protein Name
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phosphatidylinositol transfer protein, cytoplasmic 1
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Synonyms
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1110020B03Rik; 5830436L09Rik; AI662802; AI851387; C330017I21Rik; Dnr411; rdgB-beta; RDGBB; RDGBB1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000122609
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InnateDB Gene
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IDBG-213668 (Pitpnc1)
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Protein Structure
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Function |
Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro. Isoform 2 specifically binds to phosphatidylinositol but not to other phospholipids and may play a role in the phosphoinositide-mediated signaling in the neural development. {ECO:0000269PubMed:12562526}.
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Subcellular Localization |
Isoform 1: Cytoplasm.Isoform 2: Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is widely expressed. Isoform 2 is weakly expressed. In brain, isoform 2 is weakly expressed and is rather confined to the embryonic stage. In contrast, isoform 1 is widely expressed in brain, with expression in the gray matters of pre- and postnatal brains. {ECO:0000269PubMed:12562526}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1919045
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InterPro |
IPR001666
Phosphatidylinositol transfer protein
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PFAM |
PF02121
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PRINTS |
PR00391
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q8K4R4
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TrEMBL |
X1WI19
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UniProt Splice Variant |
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Entrez Gene |
71795
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UniGene |
Mm.476186
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RefSeq |
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MGI ID |
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MGI Symbol |
Pitpnc1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AL596116
AL645687
AL645905
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GenPept |
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