InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ercc8

Summary

InnateDB Protein

IDBP-535255.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ercc8

Protein Name

excision repaiross-complementing rodent repair deficiency, complementation group 8

Synonyms

2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik; Ckn1; Csa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121777

InnateDB Gene

IDBG-181454 (Ercc8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0032403	protein complex binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006979	response to oxidative stress
GO:0009411	response to UV
GO:0010165	response to X-ray
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045739	positive regulation of DNA repair
GO:0051865	protein autoubiquitination

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0016363	nuclear matrix
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex

Protein Structure and Domains

PDB ID

MGI:1919241

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F6QML7

UniProt Splice Variant

Entrez Gene

71991

UniGene

RefSeq

MGI ID

MGI Symbol

Ercc8

OMIM

CCDS

HPRD

IMGT

EMBL

AC103379 CH466568

GenPept

EDL18452