InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmgn3

Summary

InnateDB Protein

IDBP-535257.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmgn3

Protein Name

high mobility group nucleosomal binding domain 3

Synonyms

1110002A15Rik; 6330514M13Rik; BB071015; TRIP7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125616

InnateDB Gene

IDBG-188502 (Hmgn3)

Protein Structure

UniProt Annotation

Function

Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. {ECO:0000269PubMed:12185205, ECO:0000269PubMed:15082770, ECO:0000269PubMed:18502697, ECO:0000269PubMed:19651901, ECO:0000269PubMed:19885867}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the brain, eye, prostate, thyroid, kidney, testis, glial cells and insulin-producing cells of the Langerhans pancreatic islets. In the brain, expressed in the lateral olfactory tract, anterior commissure, corpus callosum, internal capsule, fornix, stria medullans, optic tract, axon bundles, Purkinje cell layer and granular layer of the cerebellum. In retina, expressed in the nuclei of cells in the inner nuclear layer including amacrine, bipolar and horizontal neurons and in the nuclei of ganglion neurons. Detected at low levels in the liver. {ECO:0000269PubMed:11356838, ECO:0000269PubMed:12185205, ECO:0000269PubMed:15082770, ECO:0000269PubMed:18502697, ECO:0000269PubMed:19651901, ECO:0000269PubMed:19885867}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0016568	chromatin modification
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus