Version 5.4
Homo sapiens Protein: TMEM17
Summary
InnateDB Protein IDBP-53527.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM17
Protein Name transmembrane protein 17
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000335094
InnateDB Gene IDBG-53525 (TMEM17)
Protein Structure
UniProt Annotation
Function Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250}.
Subcellular Localization Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the transition zone of primary cilia. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007224 smoothened signaling pathway
GO:0042384 cilium assembly
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035869 ciliary transition zone
GO:0036038 TCTN-B9D complex
GO:0060170 ciliary membrane
Protein Structure and Domains
PDB ID
InterPro IPR019184 Uncharacterised protein family, transmembrane-17
PFAM PF09799
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86X19
PhosphoSite PhosphoSite-Q86X19
TrEMBL
UniProt Splice Variant
Entrez Gene 200728
UniGene Hs.308028
RefSeq NP_938017
HUGO HGNC:26623
OMIM 614950
CCDS CCDS1871
HPRD 15528
IMGT
EMBL AC093159 AC107083 BC047439
GenPept AAH47439 AAY24048 AAY24170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca