InnateDB Protein
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IDBP-535276.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Whsc1l1
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Protein Name
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Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000117596
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InnateDB Gene
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IDBG-143943 (Whsc1l1)
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Protein Structure
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Function |
Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
6
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
Accession |
GO Term |
GO:0008270
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zinc ion binding
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GO:0018024
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histone-lysine N-methyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2142581
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InterPro |
IPR000313
PWWP domain
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PFAM |
PF00855
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PRINTS |
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PIRSF |
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SMART |
SM00293
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TIGRFAMs |
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Modification |
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SwissProt |
Q6P2L6
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PhosphoSite |
PhosphoSite-Q6P2L6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
234135
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UniGene |
Mm.471017
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RefSeq |
XP_006509168
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MGI ID |
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MGI Symbol |
Whsc1l1
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OMIM |
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CCDS |
CCDS40305
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HPRD |
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IMGT |
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EMBL |
AC156990
AC162367
AK079952
AK132725
AK156746
AK170040
BC064447
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GenPept |
AAH64447
BAC37792
BAE21322
BAE33834
BAE41526
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