Version 5.4
Mus musculus Protein: Runx2
Summary
InnateDB Protein IDBP-535298.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Runx2
Protein Name runt related transcription factor 2
Synonyms AML3; Cbf; Cbfa-1; Cbfa1; LS3; Osf2; Pebp2a1; PEBP2aA; Pebpa2a;
Species Mus musculus
Ensembl Protein ENSMUSP00000124494
InnateDB Gene IDBG-184938 (Runx2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 32 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019904 protein domain specific binding
GO:0043425 bHLH transcription factor binding
GO:0044212 transcription regulatory region DNA binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001958 endochondral ossification
GO:0002051 osteoblast fate commitment
GO:0002062 chondrocyte differentiation
GO:0002063 chondrocyte development
GO:0002076 osteoblast development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0030217 T cell differentiation
GO:0030278 regulation of ossification
GO:0032332 positive regulation of chondrocyte differentiation
GO:0035115 embryonic forelimb morphogenesis
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048863 stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:99829
InterPro IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
IPR008967 p53-like transcription factor, DNA-binding
IPR013524 Runt domain
IPR013711 Runx, C-terminal domain
IPR016554 Runt-related transcription factor RUNX
PFAM PF00853
PF08504
PRINTS PR00967
PIRSF PIRSF009374
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E0CY45
UniProt Splice Variant
Entrez Gene 12393
UniGene Mm.391017
RefSeq
MGI ID
MGI Symbol Runx2
OMIM
CCDS
HPRD
IMGT
EMBL AC165141 AL672229 AL672242
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca