Version 5.4
Mus musculus Protein: Pml
Summary
InnateDB Protein IDBP-535299.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pml
Protein Name promyelocytic leukemia
Synonyms 1200009E24Rik; AI661194; Trim19;
Species Mus musculus
Ensembl Protein ENSMUSP00000118955
InnateDB Gene IDBG-171712 (Pml)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 155 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 155 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046332 SMAD binding
Biological Process
GO:0001666 response to hypoxia
GO:0006355 regulation of transcription, DNA-templated
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007184 SMAD protein import into nucleus
GO:0008285 negative regulation of cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411 response to UV
GO:0010332 response to gamma radiation
GO:0016525 negative regulation of angiogenesis
GO:0030099 myeloid cell differentiation
GO:0030578 PML body organization
GO:0045087 innate immune response (InnateDB)
GO:0045165 cell fate commitment
GO:0045343 regulation of MHC class I biosynthetic process
GO:0048384 retinoic acid receptor signaling pathway
GO:0051457 maintenance of protein location in nucleus
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071353 cellular response to interleukin-4
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0016363 nuclear matrix
GO:0016605 PML body
Protein Structure and Domains
PDB ID MGI:104662
InterPro IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR021978 Protein of unknown function DUF3583
PFAM PF00643
PF13639
PF14634
PF12126
PRINTS
PIRSF
SMART SM00336
SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YXR5
UniProt Splice Variant
Entrez Gene 18854
UniGene Mm.483889
RefSeq XP_006510925
MGI ID
MGI Symbol Pml
OMIM
CCDS
HPRD
IMGT
EMBL AC160976
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca