InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RABAC1

Summary

InnateDB Protein

IDBP-53533.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RABAC1

Protein Name

Rab acceptor 1 (prenylated)

Synonyms

PRA1; PRAF1; YIP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000222008

InnateDB Gene

IDBG-53531 (RABAC1)

Protein Structure

UniProt Annotation

Function

General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach. {ECO:0000269PubMed:11520070}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	56 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042802	identical protein binding
GO:0070064	proline-rich region binding

Biological Process

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction