InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arl4a

Summary

InnateDB Protein

IDBP-535401.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arl4a

Protein Name

ADP-ribosylation factor-like 4A

Synonyms

AI467555; Arl4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114458

InnateDB Gene

IDBG-136104 (Arl4a)

Protein Structure

UniProt Annotation

Function

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Localization in the nucleolus is dependent by nucleotide binding. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed strongly in testis and liver. Expressed slightly in heart, spleen, lung and kidney. {ECO:0000269PubMed:10980193}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0050873	brown fat cell differentiation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:99437

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR020849 Small GTPase superfamily, Ras type
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF04670
PF08477
PF09439

PRINTS

PR00315
PR00449
PR00328

PIRSF

SMART

SM00175
SM00178
SM00173
SM00177

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt