InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: l7Rn6

Summary

InnateDB Protein

IDBP-535537.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

l7Rn6

Protein Name

lethal, Chr 7, Rinchik 6

Synonyms

0610007P06Rik; 1110002N09Rik; Hikeshi; l(7)6Rn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119806

InnateDB Gene

IDBG-198594 (l7Rn6)

Protein Structure

UniProt Annotation

Function

Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity). May also be indirectly required for organization and/or function of the secretory apparatus in Clara cells in lung. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:16157679}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008565	protein transporter activity
GO:0030544	Hsp70 protein binding

Biological Process

GO:0006606	protein import into nucleus
GO:0007030	Golgi organization
GO:0015031	protein transport
GO:0030324	lung development
GO:0034605	cellular response to heat