InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Endov

Summary

InnateDB Protein

IDBP-535553.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Endov

Protein Name

RIKEN cDNA A730011L01 gene

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119599

InnateDB Gene

IDBG-214718 (Endov)

Protein Structure

UniProt Annotation

Function

Endoribonuclease that specifically cleaves inosine- containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'- UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus.

Disease Associations

Tissue Specificity

Highest levels detected in liver with high levels also found in heart, kidney and testis. Expressed at low levels in brain. {ECO:0000269PubMed:12853604}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003727	single-stranded RNA binding
GO:0004519	endonuclease activity
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters
GO:0043566	structure-specific DNA binding