InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vegfb

Summary

InnateDB Protein

IDBP-535676.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vegfb

Protein Name

vascular endothelial growth factor B

Synonyms

VEGF-B; Vrf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120860

InnateDB Gene

IDBG-137732 (Vegfb)

Protein Structure

UniProt Annotation

Function

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. VEGF-B seems to be required for normal heart function in adult but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults. {ECO:0000269PubMed:11457758}.

Subcellular Localization

Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

Disease Associations

Tissue Specificity

Abundantly expressed in heart, brain, kidney and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042056	chemoattractant activity
GO:0042803	protein homodimerization activity
GO:0043183	vascular endothelial growth factor receptor 1 binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006493	protein O-linked glycosylation
GO:0007507	heart development
GO:0010629	negative regulation of gene expression
GO:0030154	cell differentiation
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035470	positive regulation of vascular wound healing
GO:0042493	response to drug
GO:0043524	negative regulation of neuron apoptotic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0060048	cardiac muscle contraction
GO:0060754	positive regulation of mast cell chemotaxis
GO:0060976	coronary vasculature development
GO:0070374	positive regulation of ERK1 and ERK2 cascade