InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PMCH

Summary

InnateDB Protein

IDBP-53582.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PMCH

Protein Name

pro-melanin-concentrating hormone

Synonyms

MCH;

Species

Homo sapiens

Ensembl Protein

ENSP00000332225

InnateDB Gene

IDBG-53580 (PMCH)

Protein Structure

UniProt Annotation

Function

MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. {ECO:0000269PubMed:9191099}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030354	melanin-concentrating hormone activity

Biological Process

GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007631	feeding behavior
GO:0030154	cell differentiation