Version 5.4
Mus musculus Protein: Mfn2
Summary
InnateDB Protein IDBP-535947.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mfn2
Protein Name mitofusin 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000123021
InnateDB Gene IDBG-203813 (Mfn2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0001825 blastocyst formation
GO:0006184 GTP catabolic process
GO:0006626 protein targeting to mitochondrion
GO:0007006 mitochondrial membrane organization
GO:0008053 mitochondrial fusion
GO:0045087 innate immune response (InnateDB)
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048593 camera-type eye morphogenesis
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051646 mitochondrion localization
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0015630 microtubule cytoskeleton
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2442230
InterPro IPR001401 Dynamin, GTPase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00350
PRINTS
PIRSF
SMART SM00053
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A8Y5E5
UniProt Splice Variant
Entrez Gene 170731
UniGene Mm.488699
RefSeq
MGI ID
MGI Symbol Mfn2
OMIM
CCDS
HPRD
IMGT
EMBL AL607066
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca