InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srr

Summary

InnateDB Protein

IDBP-536016.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srr

Protein Name

serine racemase

Synonyms

Srs;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118485

InnateDB Gene

IDBG-199377 (Srr)

Protein Structure

UniProt Annotation

Function

Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. {ECO:0000269PubMed:10557334, ECO:0000269PubMed:12393813, ECO:0000269PubMed:12515328, ECO:0000269PubMed:15536068, ECO:0000269PubMed:17293453}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in brain (at protein level). Brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003941	L-serine ammonia-lyase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016594	glycine binding
GO:0018114	threonine racemase activity
GO:0030165	PDZ domain binding
GO:0030170	pyridoxal phosphate binding
GO:0030378	serine racemase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0006563	L-serine metabolic process
GO:0007420	brain development
GO:0007568	aging
GO:0009069	serine family amino acid metabolic process
GO:0032496	response to lipopolysaccharide
GO:0042493	response to drug
GO:0042866	pyruvate biosynthetic process
GO:0043278	response to morphine
GO:0051289	protein homotetramerization
GO:0070179	D-serine biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0043025	neuronal cell body
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:1351636

InterPro

IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily

PFAM

PF00291

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q9QZX7

TrEMBL

Z4YMF3

UniProt Splice Variant

Entrez Gene

27364

UniGene

Mm.131443

RefSeq

MGI ID

MGI Symbol

Srr

OMIM

CCDS

HPRD

IMGT

EMBL

AL604066

GenPept