InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde4d

Summary

InnateDB Protein

IDBP-536070.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde4d

Protein Name

phosphodiesterase 4D, cAMP specific

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119583

InnateDB Gene

IDBG-181732 (Pde4d)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0046872	metal ion binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007568	aging
GO:0030593	neutrophil chemotaxis
GO:0035264	multicellular organism growth
GO:0050900	leukocyte migration
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

Protein Structure and Domains

PDB ID

MGI:99555

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AC102805 AC154376 AC154756 AC154792 AC156571 AC161585 AC163650 AC174458 CT025605 CT025614 CT030256 CT033775 DQ665892 DQ665893 DQ665894

GenPept

ABG57273 ABG57274 ABG57275 CAQ51655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca