InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mtmr2

Summary

InnateDB Protein

IDBP-536096.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtmr2

Protein Name

myotubularin related protein 2

Synonyms

6030445P13Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115906

InnateDB Gene

IDBG-134064 (Mtmr2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0016791	phosphatase activity
GO:0042803	protein homodimerization activity
GO:0052866	phosphatidylinositol phosphate phosphatase activity

Biological Process

GO:0002091	negative regulation of receptor internalization
GO:0016311	dephosphorylation
GO:0031642	negative regulation of myelination
GO:0032288	myelin assembly
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0046488	phosphatidylinositol metabolic process
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation
GO:0048666	neuron development
GO:0051262	protein tetramerization
GO:0090394	negative regulation of excitatory postsynaptic membrane potential
GO:0097062	dendritic spine maintenance
GO:2000643	positive regulation of early endosome to late endosome transport
GO:2000645	negative regulation of receptor catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005774	vacuolar membrane
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0030424	axon
GO:0043197	dendritic spine
GO:0097060	synaptic membrane
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

MGI:1924366

InterPro

IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR004182 GRAM domain
IPR010569 Myotubularin-like phosphatase domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF02893
PF06602

PRINTS

PIRSF

SMART

SM00404
SM00568

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite